Ontology highlight
ABSTRACT:
SUBMITTER: Hsu CW
PROVIDER: S-EPMC4894417 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Hsu Chia-Wen CW Zhao Jinghua J Huang Ruili R Hsieh Jui-Hua JH Hamm Jon J Chang Xiaoqing X Houck Keith K Xia Menghang M
Scientific reports 20140926
The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids, and glucose. Because endogenous chemicals bind and activate FXR, it is important to examine which xenobiotic compounds would disrupt normal receptor function. We used a cell-based human FXR β-lactamase (Bla) reporter gene assay to profile the Tox21 10K compound collection of environmental chemicals and drugs. Structure-activity relationships of FXR-active compounds revealed by this screening were then compared agains ...[more]