Ontology highlight
ABSTRACT:
SUBMITTER: Mi L
PROVIDER: S-EPMC4894440 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Mi Lan L Goryaynov Alexander A Lindquist Andre A Rexach Michael M Yang Weidong W
Scientific reports 20150323
The nuclear pore complex (NPC) is one of the largest supramolecular structures in eukaryotic cells. Its octagonal ring-scaffold perforates the nuclear envelope and features a unique molecular machinery that regulates nucleocytoplasmic transport. NPCs are composed of ~30 different nucleoporins (Nups), averaged at 8, 16 or 32 copies per NPC. This estimate has not been confirmed for individual NPCs in living cells due to the inherent difficulty of counting proteins inside single supramolecular comp ...[more]