Ontology highlight
ABSTRACT:
SUBMITTER: Cashin K
PROVIDER: S-EPMC4894445 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cashin Kieran K Gray Lachlan R LR Harvey Katherine L KL Perez-Bercoff Danielle D Lee Guinevere Q GQ Sterjovski Jasminka J Roche Michael M Demarest James F JF Drummond Fraser F Harrigan P Richard PR Churchill Melissa J MJ Gorry Paul R PR
Scientific reports 20150225
Over the past decade antiretroviral drugs have dramatically improved the prognosis for HIV-1 infected individuals, yet achieving better access to vulnerable populations remains a challenge. The principal obstacle to the CCR5-antagonist, maraviroc, from being more widely used in anti-HIV-1 therapy regimens is that the pre-treatment genotypic "tropism tests" to determine virus susceptibility to maraviroc have been developed primarily for HIV-1 subtype B strains, which account for only 10% of infec ...[more]