Ontology highlight
ABSTRACT:
SUBMITTER: Nielsen SR
PROVIDER: S-EPMC4894551 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Nature cell biology 20160418 5
Pancreatic ductal adenocarcinoma (PDAC) is a devastating metastatic disease for which better therapies are urgently needed. Macrophages enhance metastasis in many cancer types; however, the role of macrophages in PDAC liver metastasis remains poorly understood. Here we found that PDAC liver metastasis critically depends on the early recruitment of granulin-secreting inflammatory monocytes to the liver. Mechanistically, we demonstrate that granulin secretion by metastasis-associated macrophages ( ...[more]