Ontology highlight
ABSTRACT:
SUBMITTER: Dugar G
PROVIDER: S-EPMC4894983 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Dugar Gaurav G Svensson Sarah L SL Bischler Thorsten T Wäldchen Sina S Reinhardt Richard R Sauer Markus M Sharma Cynthia M CM
Nature communications 20160527
The widespread CsrA/RsmA protein regulators repress translation by binding GGA motifs in bacterial mRNAs. CsrA activity is primarily controlled through sequestration by multiple small regulatory RNAs. Here we investigate CsrA activity control in the absence of antagonizing small RNAs by examining the CsrA regulon in the human pathogen Campylobacter jejuni. We use genome-wide co-immunoprecipitation combined with RNA sequencing to show that CsrA primarily binds flagellar mRNAs and identify the maj ...[more]