Ontology highlight
ABSTRACT:
SUBMITTER: Machitani M
PROVIDER: S-EPMC4895142 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Machitani Mitsuhiro M Sakurai Fuminori F Wakabayashi Keisaku K Tomita Kyoko K Tachibana Masashi M Mizuguchi Hiroyuki H
Scientific reports 20160607
In various organisms, including nematodes and plants, RNA interference (RNAi) is a defense system against virus infection; however, it is unclear whether RNAi functions as an antivirus system in mammalian cells. Rather, a number of DNA viruses, including herpesviruses, utilize post-transcriptional silencing systems for their survival. Here we show that Dicer efficiently suppresses the replication of adenovirus (Ad) via cleavage of Ad-encoding small RNAs (VA-RNAs), which efficiently promote Ad re ...[more]