Programmable DNA Nanosystem for Molecular Interrogation.
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ABSTRACT:
SUBMITTER: Mathur D
PROVIDER: S-EPMC4895238 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Programmable DNA Nanosystem for Molecular Interrogation.
Mathur Divita D Henderson Eric R ER
Scientific reports 20160607
We describe a self-assembling DNA-based nanosystem for interrogating molecular interactions. The nanosystem contains a rigid supporting dumbbell-shaped frame, a cylindrical central core, and a mobile ring that is coaxial with the core. Motion of the ring is influenced by several control elements whose force-generating capability is based on the transition of single-stranded DNA to double-stranded DNA. These forces can be directed to act in opposition to adhesive forces between the ring and the f ...[more]
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