Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC4895353 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Zhang Hongsheng H Kang Eunchai E Wang Yaqing Y Yang Chaojuan C Yu Hui H Wang Qin Q Chen Zheyu Z Zhang Chen C Christian Kimberly M KM Song Hongjun H Ming Guo-Li GL Xu Zhiheng Z
Nature communications 20160601
Several genome- and proteome-wide studies have associated transcription and translation changes of CRMP2 (collapsing response mediator protein 2) with psychiatric disorders, yet little is known about its function in the developing or adult mammalian brain in vivo. Here we show that brain-specific Crmp2 knockout (cKO) mice display molecular, cellular, structural and behavioural deficits, many of which are reminiscent of neural features and symptoms associated with schizophrenia. cKO mice exhibit ...[more]