Dataset Information

Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic.

ABSTRACT:

Background

The acute phase proteins (APP) serum amyloid A (SAA), haptoglobin, and fibrinogen are valuable blood biomarkers in equine inflammatory diseases, but knowledge of factors influencing their concentrations in blood and peritoneal fluid (PF) of horses with colic is needed.

Objectives

The objective of this study was to investigate the influence of demographics (age, sex, breed), disease process (simple obstruction, strangulating obstruction, inflammatory), disease location, disease duration, hypovolemia, and admission hospital on concentrations of APP, lactate and white blood cell counts (WBC) in horses with colic admitted to 2 referral hospitals.

Animals

The study included 367 horses with colic admitted at 2 referral hospitals.

Methods

Prospective multicenter observational study of clinical data, as well as blood and PF biomarkers. Associations between biomarker concentrations and clinical variables were analyzed using multivariate linear regression analysis.

Results

Increasing pre-admission duration of colic was associated with increased concentrations of APP in blood and PF. Blood concentrations of SAA and fibrinogen were associated with disease process (inflammatory, strangulations, simple obstructions) in more colic duration groups (5-12 and >24 hours) than any of the other biomarkers. No relevant associations between demographic factors, hospital, or hydration status and the measured biomarkers were found.

Conclusions and clinical importance

In horses with colic, concentrations of APP are associated mainly with disease process and duration of colic and may thus be used for assessment of disease independently of demographic or geographic factors. Serum amyloid A may be a diagnostic marker for use in colic differential diagnosis, but further evaluation is needed.

SUBMITTER: Pihl TH

PROVIDER: S-EPMC4895517 | biostudies-literature | 2015 Mar-Apr

REPOSITORIES: biostudies-literature

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Publications

Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic.

Pihl T H TH Scheepers E E Sanz M M Goddard A A Page P P Toft N N Andersen P H PH Jacobsen S S

Journal of veterinary internal medicine 20150129 2

<h4>Background</h4>The acute phase proteins (APP) serum amyloid A (SAA), haptoglobin, and fibrinogen are valuable blood biomarkers in equine inflammatory diseases, but knowledge of factors influencing their concentrations in blood and peritoneal fluid (PF) of horses with colic is needed.<h4>Objectives</h4>The objective of this study was to investigate the influence of demographics (age, sex, breed), disease process (simple obstruction, strangulating obstruction, inflammatory), disease location, ...[more]

PMID: 25644457

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Dataset Information

Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic.

Background

Objectives

Animals

Methods

Results

Conclusions and clinical importance

Publications

Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic.

Similar Datasets

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