Dataset Information

Early Mortality Was Highly and Strongly Associated with Functional Status in Incident Japanese Hemodialysis Patients: A Cohort Study of the Large National Dialysis Registry.

ABSTRACT:

Background

Although dialysis is typically started in an effort to prolong survival, mortality is reportedly high in the first few months. However, it remains unclear whether this is true in Japanese patients who tend to have a better prognosis than other ethnicities, and if health conditions such as functional status (FS) at initiation of dialysis influence prognosis.

Methods

We investigated the epidemiology of early death and its association with FS using Japanese national registry data in 2007, which included 35,415 patients on incident dialysis and 7,664 with FS data. The main outcome was early death, defined as death within 3 months after initiation of hemodialysis (HD). The main predictor was FS at initiation of HD. Levels of functional disability were categorized as follows: severe (bedridden), moderate (overt difficulties in exerting basic activities of daily living), or mild/none (none or some functional disabilities).

Results

Early death remained relatively common, especially among elderly patients (overall: 7.1%; those aged ?80 years: 15.8%). Severely and even only a moderately impaired FS were significantly associated with early death after starting dialysis (adjusted risk ratios: 3.93 and 2.38, respectively). The incidence of early death in those with impaired FS increased with age (36.5% in those with severely impaired FS and aged ?80 years).

Conclusions

Early death after starting dialysis was relatively common, especially among the elderly, even in Japanese patients. Further, early death was significantly associated with impaired FS at initiation of HD.

SUBMITTER: Yazawa M

PROVIDER: S-EPMC4896445 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Early Mortality Was Highly and Strongly Associated with Functional Status in Incident Japanese Hemodialysis Patients: A Cohort Study of the Large National Dialysis Registry.

Yazawa Masahiko M Kido Ryo R Ohira Seiji S Hasegawa Takeshi T Hanafusa Norio N Iseki Kunitoshi K Tsubakihara Yoshiharu Y Shibagaki Yugo Y

PloS one 20160607 6

<h4>Background</h4>Although dialysis is typically started in an effort to prolong survival, mortality is reportedly high in the first few months. However, it remains unclear whether this is true in Japanese patients who tend to have a better prognosis than other ethnicities, and if health conditions such as functional status (FS) at initiation of dialysis influence prognosis.<h4>Methods</h4>We investigated the epidemiology of early death and its association with FS using Japanese national regist ...[more]

PMID: 27270615

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Dataset Information

Early Mortality Was Highly and Strongly Associated with Functional Status in Incident Japanese Hemodialysis Patients: A Cohort Study of the Large National Dialysis Registry.

Background

Methods

Results

Conclusions

Publications

Early Mortality Was Highly and Strongly Associated with Functional Status in Incident Japanese Hemodialysis Patients: A Cohort Study of the Large National Dialysis Registry.

Similar Datasets

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