Ontology highlight
ABSTRACT:
SUBMITTER: Ivansson EL
PROVIDER: S-EPMC4896683 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Ivansson Emma L EL Megquier Kate K Kozyrev Sergey V SV Murén Eva E Körberg Izabella Baranowska IB Swofford Ross R Koltookian Michele M Tonomura Noriko N Zeng Rong R Kolicheski Ana L AL Hansen Liz L Katz Martin L ML Johnson Gayle C GC Johnson Gary S GS Coates Joan R JR Lindblad-Toh Kerstin K
Proceedings of the National Academy of Sciences of the United States of America 20160516 22
Canine degenerative myelopathy (DM) is a naturally occurring neurodegenerative disease with similarities to some forms of amyotrophic lateral sclerosis (ALS). Most dogs that develop DM are homozygous for a common superoxide dismutase 1 gene (SOD1) mutation. However, not all dogs homozygous for this mutation develop disease. We performed a genome-wide association analysis in the Pembroke Welsh Corgi (PWC) breed comparing DM-affected and -unaffected dogs homozygous for the SOD1 mutation. The analy ...[more]