Ontology highlight
ABSTRACT:
SUBMITTER: Bagot RC
PROVIDER: S-EPMC4896746 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Bagot Rosemary C RC Cates Hannah M HM Purushothaman Immanuel I Lorsch Zachary S ZS Walker Deena M DM Wang Junshi J Huang Xiaojie X Schlüter Oliver M OM Maze Ian I Peña Catherine J CJ Heller Elizabeth A EA Issler Orna O Wang Minghui M Song Won-Min WM Stein Jason L JL Liu Xiaochuan X Doyle Marie A MA Scobie Kimberly N KN Sun Hao Sheng HS Neve Rachael L RL Geschwind Daniel D Dong Yan Y Shen Li L Zhang Bin B Nestler Eric J EJ
Neuron 20160512 5
Depression is a complex, heterogeneous disorder and a leading contributor to the global burden of disease. Most previous research has focused on individual brain regions and genes contributing to depression. However, emerging evidence in humans and animal models suggests that dysregulated circuit function and gene expression across multiple brain regions drive depressive phenotypes. Here, we performed RNA sequencing on four brain regions from control animals and those susceptible or resilient to ...[more]