Ontology highlight
ABSTRACT:
SUBMITTER: Dou YD
PROVIDER: S-EPMC4897624 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Dou Yun-De YD Zhao Han H Huang Tao T Zhao Shi-Gang SG Liu Xiao-Man XM Yu Xiao-Chen XC Ma Zeng-Xiang ZX Zhang Yu-Chao YC Liu Tao T Gao Xuan X Li Lei L Lu Gang G Chan Wai-Yee WY Gao Fei F Liu Hong-Bin HB Chen Zi-Jiang ZJ
Scientific reports 20160608
Stathmin 1 (STMN1) is a biomarker in several types of neoplasms. It plays an important role in cell cycle progression, mitosis, signal transduction and cell migration. In ovaries, STMN1 is predominantly expressed in granulosa cells (GCs). However, little is known about the role of STMN1 in ovary. In this study, we demonstrated that STMN1 is overexpressed in GCs in patients with polycystic ovary syndrome (PCOS). In mouse primary GCs, the overexpression of STMN1 stimulated progesterone production, ...[more]