Common UCP2 variants contribute to serum urate concentrations and the risk of hyperuricemia.

ABSTRACT: Elevated serum urate, which is regulated at multiple levels including genetic variants, is a risk factor for gout and other metabolic diseases. This study aimed to investigate the association between UCP2 variants and serum urate as well as hyperuricemia in a Chinese population. In total, 4332 individuals were genotyped for two common UCP2 variants, -866G/A and Ala55Val. These loci were not associated either serum urate level or with a risk of hyperuricemia in the total group of subjects. However, in females, -866G/A and Ala55Val were associated with a lower serum urate (P?=?0.006 and 0.014, seperately) and played a protective role against hyperuricemia (OR?=?0.80, P?=?0.018; OR?=?0.79, P?=?0.016). These associations were not observed in the males. After further stratification, the two loci were associated with serum urate in overweight, but not underweight females. The haplotype A-T (-866G/A-Ala55Val) was a protective factor for hyperuricemia in the female subgroup (OR?=?0.80, P?=?0.017). This present study identified a novel gene, UCP2, that influences the serum urate concentration and the risk of hyperuricemia, and the degree of association varies with gender and BMI levels.

SUBMITTER: Yang L 

PROVIDER: S-EPMC4897637 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature