A method to estimate the contribution of regional genetic associations to complex traits from summary association statistics.

ABSTRACT: Despite considerable efforts, known genetic associations only explain a small fraction of predicted heritability. Regional associations combine information from multiple contiguous genetic variants and can improve variance explained at established association loci. However, regional associations are not easily amenable to estimation using summary association statistics because of sensitivity to linkage disequilibrium (LD). We now propose a novel method, LD Adjusted Regional Genetic Variance (LARGV), to estimate phenotypic variance explained by regional associations using summary statistics while accounting for LD. Our method is asymptotically equivalent to a multiple linear regression model when no interaction or haplotype effects are present. It has several applications, such as ranking o

SUBMITTER: Pare G 

PROVIDER: S-EPMC4897708 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature