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Purification of Nanoparticles by Size and Shape.

ABSTRACT: Producing monodisperse nanoparticles is essential to ensure consistency in biological experiments and to enable a smooth translation into the clinic. Purification of samples into discrete sizes and shapes may not only improve sample quality, but also provide us with the tools to understand which physical properties of nanoparticles are beneficial for a drug delivery vector. In this study, using polymersomes as a model system, we explore four techniques for purifying pre-formed nanoparticles into discrete fractions based on their size, shape or density. We show that these techniques can successfully separate polymersomes into monodisperse fractions.

SUBMITTER: Robertson JD

PROVIDER: S-EPMC4897710 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Purification of Nanoparticles by Size and Shape.

Robertson James D JD Rizzello Loris L Avila-Olias Milagros M Gaitzsch Jens J Contini Claudia C Magoń Monika S MS Renshaw Stephen A SA Battaglia Giuseppe G

Scientific reports 20160608

Producing monodisperse nanoparticles is essential to ensure consistency in biological experiments and to enable a smooth translation into the clinic. Purification of samples into discrete sizes and shapes may not only improve sample quality, but also provide us with the tools to understand which physical properties of nanoparticles are beneficial for a drug delivery vector. In this study, using polymersomes as a model system, we explore four techniques for purifying pre-formed nanoparticles into ...[more]

PMID: 27271538

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