Once-monthly paliperidone palmitate in recently diagnosed and chronic non-acute patients with schizophrenia.

ABSTRACT: To explore the treatment response, tolerability and safety of once-monthly paliperidone palmitate (PP1M) in non-acute patients switched from oral antipsychotics, stratified by time since diagnosis as recently diagnosed (?3 years) or chronic patients (>3 years).Post hoc analysis of a prospective, interventional, single-arm, multicentre, open-label, 6-month study performed in 233 recently diagnosed and 360 chronic patients.The proportion achieving treatment response (defined as ?20% improvement in Positive and Negative Syndrome Scale [PANSS] total score from baseline to endpoint) and maintained efficacy (defined as non-inferiority in the change in PANSS total score at endpoint [Schuirmann's test]).71.4% of recently diagnosed and 59.2% of chronic patients showed a ?20% decrease in PANSS total score (p = 0.0028 between groups). Changes in PANSS Marder factors, PANSS subscales, and the proportion of patients with a Personal and Social Performance scale (PSP) total score of 71-100 were significantly greater in recently diagnosed compared with chronic patients. PP1M was well tolerated, presenting no unexpected safety findings.These data show that recently diagnosed patients treated with PP1M had a significantly higher treatment response and improved functioning, as assessed by the PSP total score, than chronic patients.

SUBMITTER: Hargarter L 

PROVIDER: S-EPMC4898156 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature