Ontology highlight
ABSTRACT:
SUBMITTER: Hu H
PROVIDER: S-EPMC4898774 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Hu Hai H Juvekar Ashish A Lyssiotis Costas A CA Lien Evan C EC Albeck John G JG Oh Doogie D Varma Gopal G Hung Yin Pun YP Ullas Soumya S Lauring Josh J Seth Pankaj P Lundquist Mark R MR Tolan Dean R DR Grant Aaron K AK Needleman Daniel J DJ Asara John M JM Cantley Lewis C LC Wulf Gerburg M GM
Cell 20160101 3
The phosphoinositide 3-kinase (PI3K) pathway regulates multiple steps in glucose metabolism and also cytoskeletal functions, such as cell movement and attachment. Here, we show that PI3K directly coordinates glycolysis with cytoskeletal dynamics in an AKT-independent manner. Growth factors or insulin stimulate the PI3K-dependent activation of Rac, leading to disruption of the actin cytoskeleton, release of filamentous actin-bound aldolase A, and an increase in aldolase activity. Consistently, PI ...[more]