Ontology highlight
ABSTRACT:
SUBMITTER: Forkuo GS
PROVIDER: S-EPMC4899155 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Forkuo Gloria S GS Guthrie Margaret L ML Yuan Nina Y NY Nieman Amanda N AN Kodali Revathi R Jahan Rajwana R Stephen Michael R MR Yocum Gene T GT Treven Marco M Poe Michael M MM Li Guanguan G Yu Olivia B OB Hartzler Benjamin D BD Zahn Nicolas M NM Ernst Margot M Emala Charles W CW Stafford Douglas C DC Cook James M JM Arnold Leggy A LA
Molecular pharmaceutics 20160510 6
Recent studies have demonstrated that subtype-selective GABAA receptor modulators are able to relax precontracted human airway smooth muscle ex vivo and reduce airway hyper-responsiveness in mice upon aerosol administration. Our goal in this study was to investigate systemic administration of subtype-selective GABAA receptor modulators to alleviate bronchoconstriction in a mouse model of asthma. Expression of GABAA receptor subunits was identified in mouse lungs, and the effects of α4-subunit-se ...[more]