Ontology highlight
ABSTRACT:
SUBMITTER: Qu G
PROVIDER: S-EPMC4899178 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Qu Guosheng G Kaushal Prem Singh PS Wang Jia J Shigematsu Hideki H Piazza Carol Lyn CL Agrawal Rajendra Kumar RK Belfort Marlene M Wang Hong-Wei HW
Nature structural & molecular biology 20160502 6
Bacterial group II introns are large catalytic RNAs related to nuclear spliceosomal introns and eukaryotic retrotransposons. They self-splice, yielding mature RNA, and integrate into DNA as retroelements. A fully active group II intron forms a ribonucleoprotein complex comprising the intron ribozyme and an intron-encoded protein that performs multiple activities including reverse transcription, in which intron RNA is copied into the DNA target. Here we report cryo-EM structures of an endogenousl ...[more]