Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC4899219 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Chen Lu L Weinberg Clarice R CR Chen Jinbo J
Statistics in medicine 20160211 16
Survival bias is difficult to detect and adjust for in case-control genetic association studies but can invalidate findings when only surviving cases are studied and survival is associated with the genetic variants under study. Here, we propose a design where one genotypes genetically informative family members (such as offspring, parents, and spouses) of deceased cases and incorporates that surrogate genetic information into a retrospective maximum likelihood analysis. We show that inclusion of ...[more]