Ontology highlight
ABSTRACT:
SUBMITTER: Colis LC
PROVIDER: S-EPMC4899226 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Colis Laureen C LC Herzon Seth B SB
Bioorganic & medicinal chemistry letters 20160430 13
(-)-Lomaiviticin A (1) is a cytotoxic bacterial metabolite that induces double-strand breaks in DNA. Here we show that the cytotoxicity of (-)-lomaiviticin A (1) is synergistically potentiated in the presence of VE-821 (7), an inhibitor of ataxia telangiectasia and Rad3-related protein (ATR). While 0.5nM 1 or 10μM 7 alone are non-lethal to K562 cells, co-incubation of the two leads to high levels of cell kill (81% and 94% after 24 and 48h, respectively). Mechanistic data indicate that cells trea ...[more]