Ontology highlight
ABSTRACT:
SUBMITTER: Tarale P
PROVIDER: S-EPMC4899583 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Tarale Prashant P Chakrabarti Tapan T Sivanesan Saravanadevi S Naoghare Pravin P Bafana Amit A Krishnamurthi Kannan K
BioMed research international 20160526
Manganese is a vital nutrient and is maintained at an optimal level (2.5-5 mg/day) in human body. Chronic exposure to manganese is associated with neurotoxicity and correlated with the development of various neurological disorders such as Parkinson's disease. Oxidative stress mediated apoptotic cell death has been well established mechanism in manganese induced toxicity. Oxidative stress has a potential to alter the epigenetic mechanism of gene regulation. Epigenetic insight of manganese neuroto ...[more]