Ontology highlight
ABSTRACT:
SUBMITTER: Benraiss A
PROVIDER: S-EPMC4899632 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Benraiss Abdellatif A Wang Su S Herrlinger Stephanie S Li Xiaojie X Chandler-Militello Devin D Mauceri Joseph J Burm Hayley B HB Toner Michael M Osipovitch Mikhail M Jim Xu Qiwu Q Ding Fengfei F Wang Fushun F Kang Ning N Kang Jian J Curtin Paul C PC Brunner Daniela D Windrem Martha S MS Munoz-Sanjuan Ignacio I Nedergaard Maiken M Goldman Steven A SA
Nature communications 20160607
The causal contribution of glial pathology to Huntington disease (HD) has not been heavily explored. To define the contribution of glia to HD, we established human HD glial chimeras by neonatally engrafting immunodeficient mice with mutant huntingtin (mHTT)-expressing human glial progenitor cells (hGPCs), derived from either human embryonic stem cells or mHTT-transduced fetal hGPCs. Here we show that mHTT glia can impart disease phenotype to normal mice, since mice engrafted intrastriatally with ...[more]