Ontology highlight
ABSTRACT:
SUBMITTER: Sikora M
PROVIDER: S-EPMC4899680 | biostudies-literature | 2016 May-Jun
REPOSITORIES: biostudies-literature
Sikora Magdalena M Tokarski Krzysztof K Bobula Bartosz B Zajdel Joanna J Jastrzębska Kamila K Cieślak Przemysław Eligiusz PE Zygmunt Magdalena M Sowa Joanna J Smutek Magdalena M Kamińska Katarzyna K Gołembiowska Krystyna K Engblom David D Hess Grzegorz G Przewlocki Ryszard R Rodriguez Parkitna Jan J
eNeuro 20160501 3
Plasticity of the brain's dopamine system plays a crucial role in adaptive behavior by regulating appetitive motivation and the control of reinforcement learning. In this study, we investigated drug- and natural-reward conditioned behaviors in a mouse model in which the NMDA receptor-dependent plasticity of dopaminoceptive neurons was disrupted. We generated a transgenic mouse line with inducible selective inactivation of the NR1 subunit in neurons expressing dopamine D1 receptors (the NR1(D1Cre ...[more]