Optimal Trend Tests for Genetic Association Studies of Heterogeneous Diseases.
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ABSTRACT:
SUBMITTER: Lee WC
PROVIDER: S-EPMC4899796 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Optimal Trend Tests for Genetic Association Studies of Heterogeneous Diseases.
Scientific reports 20160609
The Cochran-Armitage trend test is a standard procedure in genetic association studies. It is a directed test with high power to detect genetic effects that follow the gene-dosage model. In this paper, the author proposes optimal trend tests for genetic association studies of heterogeneous diseases. Monte-Carlo simulations show that the power gain of the optimal trend tests over the conventional Cochran-Armitage trend test is striking when the genetic effects are heterogeneous. The easy-to-use R ...[more]
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