Dataset Information

Longitudinal Trends in Hypertension Management and Mortality Among Octogenarians: Prospective Cohort Study.

ABSTRACT: The role of hypertension management among octogenarians is controversial. In this long-term follow-up (>10 years) study, we estimated trends in hypertension prevalence, awareness, treatment, and control among octogenarians, and evaluated the relationship of systolic blood pressure (SBP) ranges with mortality. Data were based on the English Longitudinal Study of Ageing (ELSA). Outcome measures were hypertension prevalence, awareness, treatment and control, and cardiovascular disease, and all-cause mortality events. Participants were separated into 8 categories of SBP values (<110, 110-119, 120-129, 130-139, 140-149, 150-159, 160-169, and >169 mm?Hg). Among 2692 octogenarians, mean SBP levels declined from 147 mm?Hg in 1998/2000 to 134 mm?Hg in 2012/2013. The decline was of lower magnitude in the 50 to 79 years old subgroup (n=22007). Hypertension prevalence and awareness were 40% and 13%, respectively, higher among octogenarians than the 50 to 79 years of age subgroup, but hypertension treatment rates were similar (?90%). Around 47% of the treated octogenarians achieved conventional BP targets (<140/90 mm?Hg), increasing to 59% when assessed against revised targets (<150/90 mm?Hg). All-cause mortality rates were higher (hazard ratio, 1.55; 95% confidence interval, 0.89-2.72) at lower extremes of SBP values (<110 mm?Hg). The lowest cardiovascular disease and all-cause mortality risk among treated octogenarians was observed for an SBP range of 140 to 149 mm?Hg (1.04, 0.60-1.78) and 160 to 169 mm?Hg (0.78, 0.51-1.21). An increasing trend in hypertension awareness and treatment was observed in a large sample of community-dwelling octogenarians. The results do not support the view that more stringent BP targets may be associated with lower mortality.

SUBMITTER: Dregan A

PROVIDER: S-EPMC4900418 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Longitudinal Trends in Hypertension Management and Mortality Among Octogenarians: Prospective Cohort Study.

Dregan Alex A Ravindrarajah Rathi R Hazra Nisha N Hamada Shota S Jackson Stephen H D SH Gulliford Martin C MC

Hypertension (Dallas, Tex. : 1979) 20160509 1

The role of hypertension management among octogenarians is controversial. In this long-term follow-up (>10 years) study, we estimated trends in hypertension prevalence, awareness, treatment, and control among octogenarians, and evaluated the relationship of systolic blood pressure (SBP) ranges with mortality. Data were based on the English Longitudinal Study of Ageing (ELSA). Outcome measures were hypertension prevalence, awareness, treatment and control, and cardiovascular disease, and all-caus ...[more]

PMID: 27160194

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Dataset Information

Longitudinal Trends in Hypertension Management and Mortality Among Octogenarians: Prospective Cohort Study.

Publications

Longitudinal Trends in Hypertension Management and Mortality Among Octogenarians: Prospective Cohort Study.

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