Relationship of white and gray matter abnormalities to clinical and genetic features in myotonic dystrophy type 1.

ABSTRACT:

Background

Myotonic dystrophy type 1 (DM1) represents a multisystemic disorder in which diffuse brain white and gray matter alterations related to clinical and genetic features have been described. We aimed to evaluate in the brain of adult patients with DM1 (i) white and gray matter differences, including cortical-subcortical gray matter volume and cortical thickness and (ii) their correlation with clinical disability, global neuropsychological performance and triplet expansion.

Methods

We included 24 adult genetically-confirmed DM1 patients (14 males; age: 38.5 ± 11.8 years) and 25 age- and sex-matched healthy controls (14 males; age: 38.5 ± 11.3 years) who underwent an identical brain MR protocol including high-resolution 3D T1-weighted, axial T2 FLAIR and DTI sequences.

SUBMITTER: Zanigni S 

PROVIDER: S-EPMC4900512 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature