Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC4900595 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Zhang Fenghua F Peng Bo B Chang Haiyan H Zhang Ran R Lu Fangguo F Wang Fuyan F Fang Fang F Chen Ze Z
PloS one 20160609 6
Maternally-derived antibodies (MDAs) can protect offspring against influenza virus infection but may also inhibit active immune responses. To overcome MDA- mediated inhibition, active immunization of offspring with an inactivated H5N1 whole-virion vaccine under the influence of MDAs was explored in mice. Female mice were vaccinated twice via the intraperitoneal (IP) or intranasal (IN) route with the vaccine prior to mating. One week after birth, the offspring were immunized twice via the IP or I ...[more]