Transport mechanism of a glutamate transporter homologue GltPh.
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ABSTRACT:
SUBMITTER: Ji Y
PROVIDER: S-EPMC4900748 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Transport mechanism of a glutamate transporter homologue GltPh.
Ji Yurui Y Postis Vincent L G VL Wang Yingying Y Bartlam Mark M Goldman Adrian A
Biochemical Society transactions 20160601 3
Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue GltPh, an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive studies through crystallography, MD simulations and single-molecule FRET (smFRET). Here, we summarize the recent research progress on GltPh, in the hope of gaining some insights into the transport mechanism of this aspartate transporter. ...[more]
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