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Vitamin B12 (cobalamin) deficiency in elderly patients.


ABSTRACT: Vitamin B12 or cobalamin deficiency occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), pernicious anemia (15%-20% of all cases), insufficient dietary intake and malabsorption. Food-cobalamin malabsorption, which has only recently been identified as a significant cause of cobalamin deficiency among elderly people, is characterized by the inability to release cobalamin from food or a deficiency of intestinal cobalamin transport proteins or both. We review the epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency.

SUBMITTER: Andres E 

PROVIDER: S-EPMC490077 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature

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Vitamin B12 (cobalamin) deficiency in elderly patients.

Andrès Emmanuel E   Loukili Noureddine Henoun NH   Noel Esther E   Kaltenbach Georges G   Abdelgheni Maher Ben MB   Perrin Anne Elisabeth AE   Noblet-Dick Marie M   Maloisel Frédéric F   Schlienger Jean-Louis JL   Blicklé Jean-Frédéric JF  

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20040801 3


Vitamin B12 or cobalamin deficiency occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), pernicious anemia (15%-20% of all cases), insufficient dietary intake and malabsorption. Food-cobalamin malabsorption, which  ...[more]

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