Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC4901320 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Xu Yang Y Liu Jia J He Mu M Liu Ran R Belegu Visar V Dai Ping P Liu Wei W Wang Wei W Xia Qing-Jie QJ Shang Fei-Fei FF Luo Chao-Zhi CZ Zhou Xue X Liu Su S McDonald JohnW J Liu Jin J Zuo Yun-Xia YX Liu Fei F Wang Ting-Hua TH
Scientific reports 20160610
Patients with tumors that metastasize to bone frequently suffer from debilitating pain, and effective therapies for treating bone cancer are lacking. This study employed a novel strategy in which herpes simplex virus (HSV) carrying a small interfering RNA (siRNA) targeting platelet-derived growth factor (PDGF) was used to alleviate bone cancer pain. HSV carrying PDGF siRNA was established and intrathecally injected into the cavum subarachnoidale of animals suffering from bone cancer pain and ani ...[more]