Ontology highlight
ABSTRACT:
SUBMITTER: Mullane SA
PROVIDER: S-EPMC4901342 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Mullane Stephanie A SA Werner Lillian L Rosenberg Jonathan J Signoretti Sabina S Callea Marcella M Choueiri Toni K TK Freeman Gordon J GJ Bellmunt Joaquim J
Scientific reports 20160610
Metastatic urothelial carcinoma (mUC) has a very high mutational rate and is associated with an APOBEC mutation signature. We examined the correlation of APOBEC expression with overall survival (OS) and PD-L1 expression in a cohort of 73 mUC patients. mRNA expression of APOBEC3 family of genes (A3A, A3B, A3C, A3F_a, A3F_b, A3G, A3H) was measured using Nanostring. PD-L1 expression, evaluated by immunohistochemistry, on tumor infiltrating mononuclear cells (TIMCs) and tumor cells was scored from 0 ...[more]