Proton Pump Inhibitors Accelerate Endothelial Senescence.
Ontology highlight
ABSTRACT:
SUBMITTER: Yepuri G
PROVIDER: S-EPMC4902745 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Proton Pump Inhibitors Accelerate Endothelial Senescence.
Yepuri Gautham G Sukhovershin Roman R Nazari-Shafti Timo Z TZ Petrascheck Michael M Ghebre Yohannes T YT Cooke John P JP
Circulation research 20160510 12
<h4>Rationale</h4>Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity.<h4>Objective</h4>To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI-induced vascular dysfunction.<h4>Methods and results</h4>Chronic exposure to PPIs imp ...[more]
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