Ontology highlight
ABSTRACT:
SUBMITTER: Schulze-Topphoff U
PROVIDER: S-EPMC4903020 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Schulze-Topphoff Ulf U Prat Alexandre A Prozorovski Timour T Siffrin Volker V Paterka Magdalena M Herz Josephine J Bendix Ivo I Ifergan Igal I Schadock Ines I Mori Marcelo A MA Van Horssen Jack J Schröter Friederike F Smorodchenko Alina A Han May Htwe MH Bader Michael M Steinman Lawrence L Aktas Orhan O Zipp Frauke F
Nature medicine 20090628 7
Previous proteomic and transcriptional analyses of multiple sclerosis lesions revealed modulation of the renin-angiotensin and the opposing kallikrein-kinin pathways. Here we identify kinin receptor B1 (Bdkrb1) as a specific modulator of immune cell entry into the central nervous system (CNS). We demonstrate that the Bdkrb1 agonist R838 (Sar-[D-Phe]des-Arg(9)-bradykinin) markedly decreases the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in SJL mice, whereas the Bdkrb1 an ...[more]