Ontology highlight
ABSTRACT:
SUBMITTER: Regueiro-Ren A
PROVIDER: S-EPMC4904268 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20160422 6
HIV-1 maturation inhibition (MI) has been clinically validated as an approach to the control of HIV-1 infection. However, identifying an MI with both broad polymorphic spectrum coverage and good oral exposure has been challenging. Herein, we describe the design, synthesis, and preclinical characterization of a potent, orally active, second generation HIV-1 MI, BMS-955176 (2), which is currently in Phase IIb clinical trials as part of a combination antiretroviral regimen. ...[more]