Ontology highlight
ABSTRACT:
SUBMITTER: Waster P
PROVIDER: S-EPMC4904274 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Wäster Petra P Eriksson Ida I Vainikka Linda L Rosdahl Inger I Öllinger Karin K
Scientific reports 20160613
Ultraviolet (UV) irradiation induces skin pigmentation, which relies on the intercellular crosstalk of melanin between melanocytes to keratinocytes. However, studying the separate effects of UVA and UVB irradiation reveals differences in cellular response. Herein, we show an immediate shedding of extracellular vesicles (EVs) from the plasma membrane when exposing human melanocytes to UVA, but not UVB. The EV-shedding is preceded by UVA-induced plasma membrane damage, which is rapidly repaired by ...[more]