Ontology highlight
ABSTRACT:
SUBMITTER: Loiola RA
PROVIDER: S-EPMC4904407 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Loiola Rodrigo Azevedo RA Dos Anjos Fabyana Maria FM Shimada Ana Lúcia AL Cruz Wesley Soares WS Drewes Carine Cristiane CC Rodrigues Stephen Fernandes SF Cardozo Karina Helena Morais KH Carvalho Valdemir Melechco VM Pinto Ernani E Farsky Sandra Helena SH
Scientific reports 20160613
It has been recently proposed that exposure to polychlorinated biphenyls (PCBs) is a risk factor to type 2 diabetes mellitus (DM2). We investigated this hypothesis using long-term in vivo PCB126 exposure to rats addressing metabolic, cellular and proteomic parameters. Male Wistar rats were exposed to PCB126 (0.1, 1 or 10 μg/kg of body weight/day; for 15 days) or vehicle by intranasal instillation. Systemic alterations were quantified by body weight, insulin and glucose tolerance, and blood bioch ...[more]