Activated protein C promotes neuroprotection: mechanisms and translation to the clinic.
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ABSTRACT:
SUBMITTER: Griffin JH
PROVIDER: S-EPMC4904825 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Activated protein C promotes neuroprotection: mechanisms and translation to the clinic.
Griffin John H JH Fernández José A JA Lyden Patrick D PD Zlokovic Berislav V BV
Thrombosis research 20160501
Activated protein C (APC) is a plasma serine protease that is capable of antithrombotic, anti-inflammatory, anti-apoptotic, and cell-signaling activities. Animal injury studies show that recombinant APC and some of its mutants are remarkably therapeutic for a wide range of injuries. In particular, for neurologic injuries, APC reduces damage caused by ischemia/reperfusion in the brain, by acute brain trauma, and by chronic neurodegenerative conditions. For these neuroprotective effects, APC requi ...[more]
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