Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade.
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ABSTRACT:
SUBMITTER: Schulenburg K
PROVIDER: S-EPMC4905217 | biostudies-literature | 2014 Oct-Dec
REPOSITORIES: biostudies-literature
Publications
Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade.
Schulenburg Katharina K Glatz Gabor G Remenyi Attila A Rajalingam Krishnaraj K
Molecular & cellular oncology 20141001 4
Recently, we revealed that ubiquitination of MEKK2 and MEKK3 by inhibitor of apoptosis proteins (IAPs) directly disrupts MEK5/ERK5 interaction and subsequently attenuates ERK5 activation. In addition, loss of XIAP promotes human myogenic differentiation in an ERK5-dependent manner. These results reveal another layer of MAPK regulation and a novel role for XIAP in controlling myogenic differentiation. ...[more]
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