Sonic Hedgehog factor Gli1: As good as resistant.
Ontology highlight
ABSTRACT:
SUBMITTER: Zahreddine HA
PROVIDER: S-EPMC4905224 | biostudies-literature | 2015 Jan-Mar
REPOSITORIES: biostudies-literature
Publications
Sonic Hedgehog factor Gli1: As good as resistant.
Zahreddine Hiba Ahmad HA Culjkovic-Kraljacic Biljana B Borden Katherine Lb KL
Molecular & cellular oncology 20150101 1
Chemoresistance remains a major impediment in cancer therapy. Although major progress has been made in understanding the mechanisms underlying resistance in cancer, there is still more to learn. Our studies provide evidence that Gli1 drives a novel form of drug resistance involving Phase II drug metabolism enzymes, specifically the UGT1A family. ...[more]
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