CHCHD4 links AIF to the biogenesis of respiratory chain complex I.
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ABSTRACT:
SUBMITTER: Modjtahedi N
PROVIDER: S-EPMC4905392 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
CHCHD4 links AIF to the biogenesis of respiratory chain complex I.
Modjtahedi Nazanine N Kroemer Guido G
Molecular & cellular oncology 20150729 2
During the evolution from yeast to mammals the Mia40 protein, the regulator of the redox-sensitive mitochondrial intermembrane space import machinery, has lost its membrane-anchorage segment to become CHCHD4, which interacts with the flavoprotein apoptosis-inducing factor (AIF). Our results establish CHCHD4 as the missing link between AIF deficiency and dysfunctional biogenesis of respiratory chain complexes. ...[more]
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