Examining plasma microRNA markers for colorectal cancer at different stages.
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ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC4905484 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Examining plasma microRNA markers for colorectal cancer at different stages.
Sun Yan Y Liu Yuexin Y Cogdell David D Calin George A GA Calin George A GA Sun Baocun B Kopetz Scott S Hamilton Stanley R SR Zhang Wei W
Oncotarget 20160301 10
Circulating microRNAs (miRNAs) have emerged as promising biomarkers; however, few miRNAs have been reproducible and can be used in clinical practice. In this study, we screened the levels of 754 miRNAs using TaqMan array in 50 individual plasma samples from 10 demographically matched healthy controls and 40 colorectal cancer (CRC) patients (10 each of stage I-IV) and identified 22 miRNAs associated with the presence of and stages of CRC. Then we performed the validation for 11 miRNAs in an indep ...[more]
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