Ontology highlight
ABSTRACT:
SUBMITTER: Koeppen K
PROVIDER: S-EPMC4905634 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Koeppen Katja K Hampton Thomas H TH Jarek Michael M Scharfe Maren M Gerber Scott A SA Mielcarz Daniel W DW Demers Elora G EG Dolben Emily L EL Hammond John H JH Hogan Deborah A DA Stanton Bruce A BA
PLoS pathogens 20160613 6
Bacterial outer membrane vesicle (OMV)-mediated delivery of proteins to host cells is an important mechanism of host-pathogen communication. Emerging evidence suggests that OMVs contain differentially packaged short RNAs (sRNAs) with the potential to target host mRNA function and/or stability. In this study, we used RNA-Seq to characterize differentially packaged sRNAs in Pseudomonas aeruginosa OMVs, and to show transfer of OMV sRNAs to human airway cells. We selected one sRNA for further study ...[more]