Ontology highlight
ABSTRACT:
SUBMITTER: Florescu AM
PROVIDER: S-EPMC4905689 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Florescu Ana-Maria AM Therizols Pierre P Rosa Angelo A
PLoS computational biology 20160613 6
Characterizing the link between small-scale chromatin structure and large-scale chromosome folding during interphase is a prerequisite for understanding transcription. Yet, this link remains poorly investigated. Here, we introduce a simple biophysical model where interphase chromosomes are described in terms of the folding of chromatin sequences composed of alternating blocks of fibers with different thicknesses and flexibilities, and we use it to study the influence of sequence disorder on chro ...[more]