Ontology highlight
ABSTRACT:
SUBMITTER: Bento CF
PROVIDER: S-EPMC4906231 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Bento Carla F CF Ashkenazi Avraham A Jimenez-Sanchez Maria M Rubinsztein David C DC
Nature communications 20160609
Forms of Parkinson's disease (PD) are associated with lysosomal and autophagic dysfunction. ATP13A2, which is mutated in some types of early-onset Parkinsonism, has been suggested as a regulator of the autophagy-lysosome pathway. However, little is known about the ATP13A2 effectors and how they regulate this pathway. Here we show that ATP13A2 depletion negatively regulates another PD-associated gene (SYT11) at both transcriptional and post-translational levels. Decreased SYT11 transcription is c ...[more]