Ontology highlight
ABSTRACT:
SUBMITTER: Briley D
PROVIDER: S-EPMC4906289 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Briley David D Ghirardi Valeria V Woltjer Randy R Renck Alicia A Zolochevska Olga O Taglialatela Giulio G Micci Maria-Adelaide MA
Scientific reports 20160614
Rare individuals remain cognitively intact despite the presence of neuropathology usually associated with fully symptomatic Alzheimer's disease (AD), which we refer to as Non-Demented with Alzheimer's disease Neuropathology (NDAN). Understanding the involved mechanism(s) of their cognitive resistance may reveal novel strategies to treat AD-related dementia. In the pursuit of this goal, we determined the number of hippocampal neural stem cells (NSCs) and investigated the expression of several miR ...[more]