Ontology highlight
ABSTRACT:
SUBMITTER: Chabon JJ
PROVIDER: S-EPMC4906406 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Chabon Jacob J JJ Simmons Andrew D AD Lovejoy Alexander F AF Esfahani Mohammad S MS Newman Aaron M AM Haringsma Henry J HJ Kurtz David M DM Stehr Henning H Scherer Florian F Karlovich Chris A CA Harding Thomas C TC Durkin Kathleen A KA Otterson Gregory A GA Purcell W Thomas WT Camidge D Ross DR Goldman Jonathan W JW Sequist Lecia V LV Piotrowska Zofia Z Wakelee Heather A HA Neal Joel W JW Alizadeh Ash A AA Diehn Maximilian M
Nature communications 20160610
Circulating tumour DNA (ctDNA) analysis facilitates studies of tumour heterogeneity. Here we employ CAPP-Seq ctDNA analysis to study resistance mechanisms in 43 non-small cell lung cancer (NSCLC) patients treated with the third-generation epidermal growth factor receptor (EGFR) inhibitor rociletinib. We observe multiple resistance mechanisms in 46% of patients after treatment with first-line inhibitors, indicating frequent intra-patient heterogeneity. Rociletinib resistance recurrently involves ...[more]