Pharmacogenetics-Guided Phase I Study of Capecitabine on an Intermittent Schedule in Patients with Advanced or Metastatic Solid Tumours.
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ABSTRACT:
SUBMITTER: Soo RA
PROVIDER: S-EPMC4906519 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
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Pharmacogenetics-Guided Phase I Study of Capecitabine on an Intermittent Schedule in Patients with Advanced or Metastatic Solid Tumours.
Soo Ross Andrew RA Syn Nicholas N Lee Soo-Chin SC Wang Lingzhi L Lim Xn-Yii XY Loh Marie M Tan Sing-Huang SH Zee Ying-Kiat YK Wong Andrea Li-Ann AL Chuah Benjamin B Chan Daniel D Lim Siew-Eng SE Goh Boon-Cher BC Soong Richie R Yong Wei-Peng WP
Scientific reports 20160614
The FDA-approved starting dosage of capecitabine is 1,250 mg/m(2), and market research indicates that U.S. physicians routinely prescribe 1,000 mg/m(2). Retrospective analyses however report reduced toxicity and efficacy in a subset of patients with the 3R/3R genotype of the thymidylate synthase gene enhancer region (TSER). This study sought to develop TSER genotype-specific guidelines for capecitabine dosing. Capecitabine was dose-escalated in advanced and/or metastatic cancer patients with TSE ...[more]
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