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Current and future treatment options for cystic fibrosis lung disease: latest evidence and clinical implications.


ABSTRACT: Treatment for cystic fibrosis (CF) has conventionally targeted downstream consequences of the defect such as mucus plugging and infection. More recently, significant advances have been made in treating the root cause of the disease, namely a defective CF transmembrane conductance regulator (CFTR) gene. This review summarizes current pulmonary treatment options and highlights advances in research and development of new therapies.

SUBMITTER: Edmondson C 

PROVIDER: S-EPMC4907071 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Current and future treatment options for cystic fibrosis lung disease: latest evidence and clinical implications.

Edmondson Claire C   Davies Jane C JC  

Therapeutic advances in chronic disease 20160501 3


Treatment for cystic fibrosis (CF) has conventionally targeted downstream consequences of the defect such as mucus plugging and infection. More recently, significant advances have been made in treating the root cause of the disease, namely a defective CF transmembrane conductance regulator (CFTR) gene. This review summarizes current pulmonary treatment options and highlights advances in research and development of new therapies. ...[more]

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